| dc.contributor.author | Ruth Anyango Omole | |
| dc.contributor.author | J.W. Gathirwa | |
| dc.contributor.author | Hosea Akala | |
| dc.contributor.author | Hamisi M. Malebo | |
| dc.contributor.author | Alex K. Machocho | |
| dc.contributor.author | Ahmed Hassanali | |
| dc.contributor.author | Isaiah O. Ndiege | |
| dc.date.accessioned | 2021-01-10T11:55:48Z | |
| dc.date.available | 2021-01-10T11:55:48Z | |
| dc.date.issued | 2014 | |
| dc.identifier.issn | 18733700 | |
| dc.identifier.issn | 00319422 | |
| dc.identifier.uri | https://combine.alvar.ug/handle/1/49207 | |
| dc.description.abstract | Two bisbenzylisoquinoline and one hasubanane alkaloids: (-)-pseudocurine (1), (-)-pseudoisocurine (2) and (-)-10-oxoaknadinine (3), were isolated from leaf extract of Stephania abyssinica, a plant used in traditional medicine in South Nyanza region of Kenya. They were characterized using 1D ((1)H, (13)C and DEPT) and 2D (COSY, NOESY, HMQC and HMBC) NMR techniques. (-)-Pseudocurine (1) and (-)-pseudoisocurine (2) exhibited strong to moderate anti-plasmodial activity while (-)-10-oxoaknadinine (3) showed moderate to mild activity. | |
| dc.publisher | Elsevier Limited | |
| dc.relation.ispartof | Phytochemistry | |
| dc.subject | (−)-10-oxoaknadinine anti-plasmodial activity | |
| dc.subject | (−)-Pseudocurine and (−)-pseudoisocurine | |
| dc.subject | Alkaloids | |
| dc.subject | Bisbenzylisoquinoline | |
| dc.subject | Hasubanane | |
| dc.subject | Menispermerceae | |
| dc.subject | Stephania abyssinica | |
| dc.subject.mesh | Alkaloids/chemistry | |
| dc.subject.mesh | Antimalarials/chemistry | |
| dc.subject.mesh | Benzylisoquinolines/chemistry | |
| dc.subject.mesh | Magnetic Resonance Spectroscopy | |
| dc.subject.mesh | Molecular Structure | |
| dc.subject.mesh | Plasmodium falciparum/drug effects | |
| dc.subject.mesh | Stephania/chemistry | |
| dc.title | Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae) | |
| dc.type | journal article | |
| dc.identifier.doi | 10.1016/j.phytochem.2014.03.026 | |
| dc.identifier.pmid | 24735823 | |
| dc.identifier.mag | 2066187892 | |
| dc.identifier.lens | 076-479-167-736-007 | |
| dc.identifier.volume | 103 | |
| dc.identifier.spage | 123 | |
| dc.identifier.epage | 128 | |
| dc.subject.chemicals | Alkaloids | |
| dc.subject.chemicals | Antimalarials | |
| dc.subject.chemicals | Benzylisoquinolines | |
| dc.subject.lens-fields | Chemistry | |
| dc.subject.lens-fields | DEPT | |
| dc.subject.lens-fields | Stephania abyssinica | |
| dc.subject.lens-fields | Traditional medicine | |
| dc.subject.lens-fields | Botany |
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