Abstract
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Two bisbenzylisoquinoline and one hasubanane alkaloids: (-)-pseudocurine (1), (-)-pseudoisocurine (2) and (-)-10-oxoaknadinine (3), were isolated from leaf extract of Stephania abyssinica, a plant used in traditional medicine in South Nyanza region of Kenya. They were characterized using 1D ((1)H, (13)C and DEPT) and 2D (COSY, NOESY, HMQC and HMBC) NMR techniques. (-)-Pseudocurine (1) and (-)-pseudoisocurine (2) exhibited strong to moderate anti-plasmodial activity while (-)-10-oxoaknadinine (3) showed moderate to mild activity.
Subjects
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(−)-10-oxoaknadinine anti-plasmodial activity • (−)-Pseudocurine and (−)-pseudoisocurine • Alkaloids • Bisbenzylisoquinoline • Hasubanane • Menispermerceae • Stephania abyssinica • Alkaloids/chemistry • Antimalarials/chemistry • Benzylisoquinolines/chemistry • Magnetic Resonance Spectroscopy • Molecular Structure • Plasmodium falciparum/drug effects • Stephania/chemistry • Alkaloids • Antimalarials • Benzylisoquinolines • Chemistry • DEPT • Stephania abyssinica • Traditional medicine • Botany