combine@alvar.ug

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire

Show simple record

dc.contributor.author Bernadin Ahouty
dc.contributor.author Mathurin Koffi
dc.contributor.author Hamidou Ilboudo
dc.contributor.author Gustave Simo
dc.contributor.author Enock Matovu
dc.contributor.author Julius Mulindwa
dc.contributor.author Christiane Hertz-Fowler
dc.contributor.author Bruno Bucheton
dc.contributor.author Issa Sidibé
dc.contributor.author Vincent Jamonneau
dc.contributor.author Annette MacLeod
dc.contributor.author Harry Noyes
dc.contributor.author Simon-Pierre N’Guetta
dc.date.accessioned 2021-01-11T13:51:41Z
dc.date.available 2021-01-11T13:51:41Z
dc.date.issued 2017
dc.identifier.uri https://combine.alvar.ug/handle/1/49452
dc.description.abstract Human African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. Long regarded as an invariably fatal disease, there is increasing evidence that infection by T. b. gambiense can result in a wide range of clinical outcomes, including latent infections, which are long lasting infections with no parasites detectable by microscopy. The determinants of this clinical diversity are not well understood but could be due in part to parasite or host genetic diversity in multiple genes, or their interactions. A candidate gene association study was conducted in Cote d9Ivoire using a case-control design which included a total of 233 subjects (100 active HAT cases, 100 controls and 33 latent infections). All three possible pairwise comparisons between the three phenotypes were tested using 96 SNPs in 16 candidate genes (IL1, IL4, IL4R, IL6, IL8, IL10, IL12, IL12R, TNFA, INFG, MIF, APOL1, HPR, CFH, HLA-A and HLA-G). Data from 77 SNPs passed quality control. There were suggestive associations at three loci in IL6 and TNFA in the comparison between active cases and controls, one SNP in each of APOL1, MIF and IL6 in the comparison between latent infections and active cases and seven SNP in IL4, HLA-G and TNFA between latent infections and controls. No associations remained significant after Bonferroni correction, but the Benjamini Hochberg false discovery rate test indicated that there were strong probabilities that at least some of the associations were genuine. The excess of associations with latent infections despite the small number of samples available suggests that these subjects form a distinct genetic cluster different from active HAT cases and controls, although no clustering by phenotype was observed by principle component analysis. This underlines the complexity of the interactions existing between host genetic polymorphisms and parasite diversity.
dc.publisher Cold Spring Harbor Laboratory
dc.title Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire
dc.type Preprint
dc.identifier.doi 10.1101/186718
dc.identifier.mag 2752314148
dc.identifier.lens 022-449-866-224-880
dc.identifier.spage 186718
dc.subject.lens-fields SNP
dc.subject.lens-fields Single-nucleotide polymorphism
dc.subject.lens-fields False discovery rate
dc.subject.lens-fields Immunology
dc.subject.lens-fields Tropical disease
dc.subject.lens-fields African trypanosomiasis
dc.subject.lens-fields Genetics
dc.subject.lens-fields Candidate gene
dc.subject.lens-fields Genetic diversity
dc.subject.lens-fields Locus (genetics)
dc.subject.lens-fields Biology


This record appears in the collections of the following institution(s)

Show simple record

Search Entire Database


Browse

My Account