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Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

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dc.contributor.author Isabel Rodriguez-Barraquer
dc.contributor.author Emmanuel Arinaitwe
dc.contributor.author Prasanna Jagannathan
dc.contributor.author Moses R. Kamya
dc.contributor.author PJ Rosenthal
dc.contributor.author John Rek
dc.contributor.author Grant Dorsey
dc.contributor.author Joaniter Nankabirwa
dc.contributor.author Sarah G. Staedke
dc.contributor.author Maxwell Kilama
dc.contributor.author Chris Drakeley
dc.contributor.author Isaac Ssewanyana
dc.contributor.author David L. Smith
dc.contributor.author Bryan Greenhouse
dc.date.accessioned 2021-01-11T13:51:40Z
dc.date.available 2021-01-11T13:51:40Z
dc.date.issued 2017
dc.identifier.uri https://combine.alvar.ug/handle/1/49419
dc.description.abstract Malaria immunity is complex and multi-faceted, and fundamental gaps remain in our understanding of how it develops. Here, we use detailed clinical and entomological data from three parallel cohort studies conducted across the malaria transmission spectrum in Uganda to quantify the development of immunity against symptomatic Plasmodium falciparum as a function of age and transmission intensity. We focus on: anti-parasite immunity (i.e; ability to control parasite densities) and anti-disease immunity (i.e; ability to tolerate higher parasite densities without fever). Our findings suggest a strong effect of age on both types of immunity, that remains significant after adjusting for cumulative exposure. They also show a non-linear effect of transmission intensity, where children experiencing the lowest transmission appear to develop immunity faster than those experiencing higher transmission. These findings illustrate how anti-parasite and anti-disease immunity develop in parallel, reducing the probability of experiencing symptomatic malaria upon each subsequent P. falciparum infection.
dc.publisher Cold Spring Harbor Laboratory
dc.title Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
dc.type Preprint
dc.identifier.doi 10.1101/191197
dc.identifier.mag 2952188166
dc.identifier.lens 012-166-182-806-967
dc.identifier.spage 191197
dc.subject.lens-fields Cohort study
dc.subject.lens-fields Immunology
dc.subject.lens-fields Malaria
dc.subject.lens-fields Plasmodium falciparum
dc.subject.lens-fields Disease
dc.subject.lens-fields Immunity
dc.subject.lens-fields Cumulative Exposure
dc.subject.lens-fields Transmission (mechanics)
dc.subject.lens-fields Medicine
dc.subject.lens-fields Parasite hosting


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