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Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda

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dc.contributor.author Su Yun Kang
dc.contributor.author Katherine E. Battle
dc.contributor.author Harry S. Gibson
dc.contributor.author Laura V. Cooper
dc.contributor.author Kilama Maxwell
dc.contributor.author Moses R. Kamya
dc.contributor.author Steven W. Lindsay
dc.contributor.author Grant Dorsey
dc.contributor.author Bryan Greenhouse
dc.contributor.author Isabel Rodriguez-Barraquer
dc.contributor.author Robert C. Reiner
dc.contributor.author David L. Smith
dc.contributor.author Donal Bisanzio
dc.date.accessioned 2021-01-11T13:51:40Z
dc.date.available 2021-01-11T13:51:40Z
dc.date.issued 2018
dc.identifier.uri https://combine.alvar.ug/handle/1/49418
dc.description.abstract Heterogeneity in malaria transmission has household, temporal, and spatial components. These factors are relevant for improving the efficiency of malaria control by targeting heterogeneity. To quantify variation, we analyzed mosquito counts from entomological surveillance conducted at three study sites in Uganda that varied in malaria transmission intensity. Using a Bayesian zero-inflated negative binomial model, validated via a comprehensive simulation study, we quantified household differences in malaria exposure and examined its spatial distribution. We found that housing quality explained large variation among households in mosquito counts. In each site, there was evidence for hot and cold spots, spatial patterns associated with urbanicity, elevation, or other environmental covariates. We also found some differences in the hotspots in rainy vs. dry seasons or before vs. after control. This work identified methods for quantifying heterogeneity in malaria exposure and offered a critical evaluation of spatially targeting interventions at malaria hotspots.
dc.publisher Cold Spring Harbor Laboratory
dc.title Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda
dc.type Preprint
dc.identifier.doi 10.1101/299529
dc.identifier.mag 2950521989
dc.identifier.lens 011-962-457-966-021
dc.identifier.spage 299529
dc.subject.lens-fields Hotspot (geology)
dc.subject.lens-fields Spatial ecology
dc.subject.lens-fields Negative binomial distribution
dc.subject.lens-fields Spatial distribution
dc.subject.lens-fields Malaria
dc.subject.lens-fields Cold spot
dc.subject.lens-fields Malaria vector
dc.subject.lens-fields Malaria control
dc.subject.lens-fields Biology
dc.subject.lens-fields Environmental health


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