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Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever

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dc.contributor.author Elia Vajana
dc.contributor.author Mario Barbato
dc.contributor.author Licia Colli
dc.contributor.author Marco Milanesi
dc.contributor.author Estelle Rochat
dc.contributor.author Enrico Fabrizi
dc.contributor.author Christopher Mukasa
dc.contributor.author Marcello Del Corvo
dc.contributor.author Charles Masembe
dc.contributor.author Vincent B. Muwanika
dc.contributor.author Fredrick Kabi
dc.contributor.author Tad S. Sonstegard
dc.contributor.author Heather J. Huson
dc.contributor.author Riccardo Negrini
dc.contributor.author Stéphane Joost
dc.contributor.author Paolo Ajmone-Marsan
dc.date.accessioned 2021-01-11T13:51:39Z
dc.date.available 2021-01-11T13:51:39Z
dc.date.issued 2018
dc.identifier.uri https://combine.alvar.ug/handle/1/49394
dc.description.abstract East Coast fever (ECF) is a fatal sickness affecting cattle populations of eastern, central, and southern Africa. The disease is transmitted by the tick Rhipicephalus appendiculatus, and caused by the protozoan Theileria parva parva, which invades host lymphocytes and promotes their clonal expansion. Importantly, indigenous cattle show tolerance to infection in ECF-endemically stable areas. Here, the putative genetic bases underlying ECF-tolerance were investigated using molecular data and epidemiological information from 823 indigenous cattle from Uganda. Vector distribution and host infection risk were estimated over the study area and subsequently tested as triggers of local adaptation by means of landscape genomics analysis. We identified 41 and seven candidate adaptive loci for tick resistance and infection tolerance, respectively. Among the genes associated with the candidate adaptive loci are PRKG1 and SLA2. PRKG1 was already described as associated with tick resistance in indigenous South African cattle, due to its role into inflammatory response. SLA2 is part of the regulatory pathways involved into lymphocytes9 proliferation. Additionally, local ancestry analysis suggested the zebuine origin of the genomic region candidate for tick resistance.
dc.publisher Cold Spring Harbor Laboratory
dc.title Combining landscape genomics and ecological modelling to investigate local adaptation of indigenous Ugandan cattle to East Coast fever
dc.type Preprint
dc.identifier.doi 10.1101/315184
dc.identifier.mag 2800893983
dc.identifier.lens 005-107-097-519-847
dc.identifier.spage 315184
dc.subject.lens-fields Genomics
dc.subject.lens-fields East Coast fever
dc.subject.lens-fields Disease
dc.subject.lens-fields Tick
dc.subject.lens-fields Local adaptation
dc.subject.lens-fields Ecological modelling
dc.subject.lens-fields Indigenous
dc.subject.lens-fields Locus (genetics)
dc.subject.lens-fields Biology
dc.subject.lens-fields Zoology


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