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Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda

Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda

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dc.contributor.author Winters Muttamba
dc.contributor.author John K. Lusiba
dc.contributor.author Loryndah Olive Namakula
dc.contributor.author Pauline Byakika-Kibwika
dc.contributor.author Francis Ssali
dc.contributor.author Henry Ddungu
dc.contributor.author Levicatus Mugenyi
dc.contributor.author Noah Kiwanuka
dc.contributor.author Rogers Sekibira
dc.contributor.author Cissy Kityo
dc.contributor.author Dorothy Keyune
dc.contributor.author Susan Acana
dc.contributor.author Ambrose Musinguzi
dc.contributor.author Ayub Masasi
dc.contributor.author Joseph Byamugisha
dc.contributor.author David Mpanju
dc.contributor.author Walter Jack Musoki
dc.contributor.author Hellen Aanyu Tukamuhebwa
dc.contributor.author Fred Nakwagala
dc.contributor.author Bernard Sentalo Bagaya
dc.contributor.author Alex Kayongo
dc.contributor.author Ivan Kimuli
dc.contributor.author Rebecca Nantanda
dc.contributor.author Winceslaus Katagira
dc.contributor.author Esther Buregyeya
dc.contributor.author Rosemary K Byanyima
dc.contributor.author Baterana Byarugaba
dc.contributor.author Trishul Siddharthan
dc.contributor.author Henry Mwebesa
dc.contributor.author Olaro Charles
dc.contributor.author Moses Joloba
dc.contributor.author William Bazeyo
dc.contributor.author Bruce Kirenga
dc.date.accessioned 2021-01-11T13:51:39Z
dc.date.available 2021-01-11T13:51:39Z
dc.date.issued 2020
dc.identifier.uri https://combine.alvar.ug/handle/1/49388
dc.description.abstract Abstract Introduction Evidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging. However, very few African countries have undertaken the collection and processing of CCP. The aim of this study was to assess the feasibility of collecting and processing of CCP, in preparation for a randomized clinical trial of CCP for treatment of COVID-19 in Uganda. Methods In a cross-sectional study, persons with documented evidence of recovery from COVID-19 in Uganda were contacted and screened for blood donation via telephone calls. Those found eligible were asked to come to the blood donation centre for further screening and consent. Whole blood collection was undertaken from which plasma was processed. Plasma was tested for transfusion transmissible infections (TTIs) and anti-SARS CoV-2 antibody titers. SARS-CoV-2 testing was also done on nasopharyngeal swabs from the donors. Results 192 participants were contacted of whom 179 (93.2%) were eligible to donate. Of the 179 eligible, 23 (12.8%) were not willing to donate and reasons given included: having no time 7(30.4%), fear of being retained at the COVID-19 treatment center 10 (43.5%), fear of stigma in the community 1 (4.3%), phobia for donating blood 1 (4.3%), religious issues 1 (4.4%), lack of interest 2 (8.7%) and transport challenges 1 (4.3%). The median age was 30 years and females accounted for 3.7% of the donors. A total of 30 (18.5%) donors tested positive for different TTIs. Antibody titer testing demonstrated titers of more than 1:320 for all the 72 samples tested. Age greater than 46 years and female gender were associated with higher titers though not statistically significant. Conclusion CCP collection and processing is possible in Uganda. However, concerns about stigma and lack of time, interest or transport need to be addressed in order to maximize donations.
dc.publisher Cold Spring Harbor Laboratory
dc.title Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda
dc.type Preprint
dc.identifier.doi 10.1101/2020.10.29.20222067
dc.identifier.mag 3095622955
dc.identifier.lens 002-857-587-574-359
dc.subject.lens-fields Internal medicine
dc.subject.lens-fields Whole blood
dc.subject.lens-fields Randomized controlled trial
dc.subject.lens-fields Antibody titer
dc.subject.lens-fields Blood donor
dc.subject.lens-fields Treatment center
dc.subject.lens-fields Coronavirus disease 2019 (COVID-19)
dc.subject.lens-fields Convalescent plasma
dc.subject.lens-fields Titer
dc.subject.lens-fields Medicine


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