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Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis.

Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis.

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dc.contributor.author Davy Vancampfort
dc.contributor.author Joseph Firth
dc.contributor.author Felipe Barreto Schuch
dc.contributor.author Simon Rosenbaum
dc.contributor.author James Mugisha
dc.contributor.author Mats Hallgren
dc.contributor.author Michel Probst
dc.contributor.author Philip B. Ward
dc.contributor.author Fiona Gaughran
dc.contributor.author Marc De Hert
dc.contributor.author André F. Carvalho
dc.contributor.author Brendon Stubbs
dc.date.accessioned 2021-01-10T11:55:58Z
dc.date.available 2021-01-10T11:55:58Z
dc.date.issued 2017
dc.identifier.issn 17238617
dc.identifier.uri https://combine.alvar.ug/handle/1/49324
dc.description.abstract People with severe mental illness (schizophrenia, bipolar disorder or major depressive disorder) die up to 15 years prematurely due to chronic somatic comorbidities. Sedentary behavior and low physical activity are independent yet modifiable risk factors for cardiovascular disease and premature mortality in these people. A comprehensive meta-analysis exploring these risk factors is lacking in this vulnerable population. We conducted a meta-analysis investigating sedentary behavior and physical activity levels and their correlates in people with severe mental illness. Major electronic databases were searched from inception up to April 2017 for articles measuring sedentary behavior and/or physical activity with a self-report questionnaire or an objective measure (e.g., accelerometer). Random effects meta-analyses and meta-regression analyses were conducted. Sixty-nine studies were included (N=35,682; 39.5% male; mean age 43.0 years). People with severe mental illness spent on average 476.0 min per day (95% CI: 407.3-545.4) being sedentary during waking hours, and were significantly more sedentary than age- and gender-matched healthy controls (p=0.003). Their mean amount of moderate or vigorous physical activity was 38.4 min per day (95% CI: 32.0-44.8), being significantly lower than that of healthy controls (p=0.002 for moderate activity, p<0.001 for vigorous activity). People with severe mental illness were significantly less likely than matched healthy controls to meet physical activity guidelines (odds ratio = 1.5; 95% CI: 1.1-2.0, p<0.001, I2 =95.8). Lower physical activity levels and non-compliance with physical activity guidelines were associated with male gender, being single, unemployment, fewer years of education, higher body mass index, longer illness duration, antidepressant and antipsychotic medication use, lower cardiorespiratory fitness and a diagnosis of schizophrenia. People with bipolar disorder were the most physically active, yet spent most time being sedentary. Geographical differences were detected, and inpatients were more active than outpatients and those living in the community. Given the established health benefits of physical activity and its low levels in people with severe mental illness, future interventions specifically targeting the prevention of physical inactivity and sedentary behavior are warranted in this population.
dc.description.sponsorship National Institute for Health Research
dc.description.sponsorship Stanley Medical Research Institute
dc.description.sponsorship King's College London
dc.description.sponsorship Care South London at King's College Hospital National Health Service (NHS) Foundation Trust
dc.description.sponsorship NIHR Biomedical Research Centre at South London
dc.description.sponsorship Maudsley NHS Foundation Trust
dc.publisher Wiley-Blackwell
dc.relation.ispartof World psychiatry : official journal of the World Psychiatric Association (WPA)
dc.subject Physical activity
dc.subject bipolar disorder
dc.subject cardiovascular disease
dc.subject major depressive disorder
dc.subject physical activity guidelines
dc.subject premature mortality
dc.subject schizophrenia
dc.subject sedentary behavior
dc.subject severe mental illness
dc.title Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis.
dc.type journal article
dc.identifier.doi 10.1002/wps.20458
dc.identifier.pmid 28941119
dc.identifier.mag 2757112350
dc.identifier.pmc PMC5608847
dc.identifier.lens 134-295-896-700-931
dc.identifier.volume 16
dc.identifier.issue 3
dc.identifier.spage 308
dc.identifier.epage 315
dc.subject.lens-fields Psychiatry
dc.subject.lens-fields Physical fitness
dc.subject.lens-fields Psychological intervention
dc.subject.lens-fields Bipolar disorder
dc.subject.lens-fields Mental illness
dc.subject.lens-fields Major depressive disorder
dc.subject.lens-fields Diagnosis of schizophrenia
dc.subject.lens-fields Population
dc.subject.lens-fields Medicine
dc.subject.lens-fields Schizophrenia


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