Abstract
:
The known flemingins A− C( 1−3) and nine new chalcones, named flemingins G− O( 4−12), along with deoxyhomoflemingin (13) and emodin (14) were isolated from a leaf extract of Flemingia grahamiana. The isolated chalcones were found to have a geranyl substituent modified into a chromene ring possessing a residual chain, as shown by spectroscopic methods. The leaf extract showed an IC50 value of 5.9 μg/mL in a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The chalcones flemingins A, B, C, G, and H were active in the DPPH radical scavenging assay (ED50 4.4−8.9 μM), while flemingins A and C showed cytotoxicity against MCF-7 human breast cancer cells (IC50 8.9 and 7.6 μM, respectively).
Subjects
:
Antineoplastic Agents, Phytogenic/chemistry • Antioxidants/chemistry • Biphenyl Compounds • Chalcones/chemistry • Drug Screening Assays, Antitumor • Fabaceae/chemistry • Female • Free Radical Scavengers/chemistry • Humans • Molecular Structure • Phenols/chemistry • Picrates • Plant Extracts/chemistry • Plant Leaves/chemistry • Antineoplastic Agents, Phytogenic • Antioxidants • Biphenyl Compounds • Chalcones • Free Radical Scavengers • Phenols • Picrates • Plant Extracts • flemingin G • flemingin H • 1,1-diphenyl-2-picrylhydrazyl • Cytotoxicity • Nuclear chemistry • Chemistry • IC50 • Scavenging • Antioxidant • Emodin • Substituent • Flemingia • DPPH • Stereochemistry